High Creatinine
High creatinine is a signal that the kidneys may be under strain — a marker to investigate calmly, not a diagnosis on its own.
Medically reviewed by the RIIMS nephrology team · Last updated: June 2026
What does high creatinine mean?
Creatinine is a natural waste product your muscles make, which healthy kidneys filter out through urine. It is a marker, not a disease. When kidney filtering slows, creatinine builds up in the blood, but dehydration, certain medicines, infection, urinary obstruction, diabetes, high blood pressure or even a muscular build can all raise it. Because two people with the same creatinine can have very different kidney function, it is read alongside eGFR, urine protein, potassium and your history, never the number alone.
Symptoms to watch for
- Tiredness and low energy
- Swelling in feet or face
- Foamy or reduced urine
- Loss of appetite, nausea
- Itching or dry skin
- High blood pressure
When to consult a kidney doctor
If creatinine stays high across repeat reports or eGFR is falling, or you have diabetes, blood pressure or swelling, seek a nephrology opinion early. A sudden drop in urine, breathlessness or very high potassium needs prompt medical care.